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Invitrogen™ FOXP3 Monoclonal Antibody (3G3), FITC
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Catalog No. 01676621
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100 μL
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Catalog No. Quantity
01-676-621 100 μL
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Catalog No. 01-676-621 Supplier Invitrogen™ Supplier No. MA141628
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Description

Mouse Monoclonal Antibody

MA1-41628 is derived from full-length His-tagged mouse FOXP3. The precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. Cross reacts with Human and Mouse.

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FOXP3
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone 3G3
Concentration 0.86 mg/mL
Conjugate FITC
Formulation 50mM sodium borate with 0.05% sodium azide
Gene Foxp3
Gene Accession No. Q99JB6, Q9BZS1
Gene Alias AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
Gene Symbols Foxp3
Host Species Mouse
Immunogen Full-length His-tagged murine FOXP3.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20371, 50943
Target Species Human, Mouse
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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WARNING: Cancer - www.P65Warnings.ca.gov
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