Invitrogen™ FPR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA141398

Catalog No. 01-675-527

Description

Suggested positive control: human liver protein, liver lysate.

FPR1 is a member of chemoattractant/chemokine GPCRs expressed mainly on leukocytes, neutrophils and monocytes. FPR1 is a seven transmembrane pertussis toxin-sensitive GPCR and binds to formylated peptides generated by bacteria resulting in leukocyte trafficking to the site of inflammation. Ligand binding to FPR results in activation of multiple effectors including phospholipase C leading to calcium mobilization and PKC activation. Other implications of FPR signaling include polarization of actin cytoskeleton, activation of various integrins, increased cell migration, phagocytosis, degranulation and release of reactive oxygen intermediates.

Specifications

• Antigen: FPR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FPR1
• Gene Alias: fMet-Leu-Phe receptor; fMLF-R; FMLP; fMLP receptor; formyl peptide receptor 1; FPR; Fpr receptor; FPR1; FPR-1; lipoxin A4 receptor; LXA4R; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14293, 2357
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.0 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P21462, P33766
• Gene Symbols: FPR1
• Immunogen: Synthetic peptide corresponding to residues 176-190 of humanFPR1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Monkey
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov