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Tocris Bioscience™ FRAX 597

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Quantity:
10 mg
50 mg
Description
FRAX 597 is a potent group I PAK inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). FRAX 597 exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 >10 μM for PAK4). FRAX 597 inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.
Specifications
Specifications
Chemical Name or Material | FRAX 597 |
CAS | 1286739-19-2 |
Synonym | 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one |
Quantity | 50 mg |
Solubility | Soluble to 20mM in DMSO |
Target | PAK Inhibitors |
Molecular Formula | C29H28ClN7OS |
Formula Weight | 558.1 |
Physical Form | Solid |
Color | Yellow |
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For Research Use Only.
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