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FRMPD4 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501734171 Shop All Proteintech Group Inc Products
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50-173-4171 150 μL
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Catalog No. 50-173-4171 Supplier Proteintech Group Inc Supplier No. 239431AP150UL
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Description

Rabbit Polyclonal Antibody

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus. It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions. Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width; conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology. The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintece of excitatory synaptic transmission.

Specifications

Antigen FRMPD4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.31 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene FRMPD4
Gene Accession No. Q14CM0
Gene Alias FRMPD4, KIAA0316, PDZD10, PDZK10, Preso
Gene Symbols FRMPD4
Host Species Rabbit
Immunogen FRMPD4 Fusion Protein Ag21050
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9758
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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