FSHR Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 226651AP
DescriptionFollicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Follitropin receptor, FSH R, FSHR, FSHRO, LGR1, ODG1|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot|
|FSHR Fusion Protein Ag18158|
|Antigen Affinity Chromatography|
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