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Apexbio Technology LLC PF-04217903(Synonyms: PF04217903, PF 04217903, PF-4217903, PF4217903, MET inhibitor PF-04217903), 25mg, CAS: 956905-27-4.
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Supplier:  Apexbio Technology LLC A509625

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PF-04217903 (CAS 956905-27-4) is a selective ATP-competitive inhibitor targeting the receptor tyrosine kinase c-Met with a reported Ki value of 4 8 nM Aberrant activation or amplification of c-Met signaling contributes significantly to tumor cell proliferation angiogenesis and metastasis PF-04217903 exhibits high selectivity for c-Met over numerous other kinases and inhibits various c-Met mutants including R988C V1092I H1094R and T1010I In cellular studies using lines such as GTL-16 and H1993 PF-04217903 inhibits proliferation and induces apoptosis In vivo it effectively reduces c-Met phosphorylation and tumor growth suggesting potential as a research tool for investigating c-Met-related oncogenic pathways

Catalog No. 50-000-60805


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