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FUS Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501557316
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50-155-7316 20 μL
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Catalog No. 50-155-7316 Supplier Bethyl Laboratories, Inc Supplier No. A300294AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predict

FUS/TLS was originally described as fused in Sarcoma is actually related to a number of different cellular processes and correlated to several diseases. FUS binds DNA as a single or double strand, and acts as a site for transcription factors to recognize. Since FUS is well-documented to be involved in liposarcoma, lipoma and leukaemia, it is believed that when its normal housekeeping functions related to transcription are disrupted, normal cells become cancerous. Interestingly, FUS is also associated with the fatal neuron disorder amyotrophic lateral sclerosis; interruption of its normal RNA-binding functions leads to incorrect cellular localization and leads to pathologies of the neuron. Thus, FUS regulation of cellular functions is a critical component of maintece of healthy cells.

Specifications

Antigen FUS
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene FUS
Gene Accession No. P35637, P56959
Gene Alias ALS6, FUS1, HNRNPP2, POMP75, TLS, 75 kDa DNA-pairing protein, RNA-binding protein FUS, fus-like protein, fusion gene in myxoid liposarcoma, heterogeneous nuclear ribonucleoprotein P2, oncogene FUS, oncogene TLS, translocated in liposarcoma protein
Gene Symbols Fus
Host Species Rabbit
Immunogen Between 500 and C-term
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 233908, 2521
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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