Abnova™ FXYD2 Recombinant Protein
Human FXYD2 full-length ORF with GST-tag at N-terminal
Supplier: Abnova™ H00000486P0110
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Theoretical MW: 32.78kDa
- Preparation Method: In vitro wheat germ expression system
- Purification: Glutathione Sepharose 4 Fast Flow
- Storage Buffer: 50mM Tris-HCI, 10mM reduced Glutathione, pH=8.0 in the elution buffer
ELISA, Western Blotting (Recombinant Protein), Antibody Production, Protein Array
|50mM Tris HCl, 10mM reduced Glutathione, pH 8 in the Elution Buffer
|Glutathione Sepharose 4 Fast Flow
|Wheat Germ (in vitro)
|Antibody Production, Protein Array, ELISA, Western Blot
|FXYD2 (Human) Recombinant Protein (P01)
|In vitro wheat germ expression system
|12.5% SDS-PAGE Stained with Coomassie Blue.
|Wheat Germ (in vitro)
|Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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