Apexbio Technology LLC G-15(Synonyms: G15, GPER antagonist G15, GPER receptor antagonist G15, GPER inhibitor G15, GPER-selective antagonist G-15), 10mg, CAS: 1161002-05-6.

Supplier:  Apexbio Technology LLC B546910

G-15 (CAS 1161002-05-6) is a selective antagonist of G protein-coupled receptor 30 (GPR30) with a Ki of approximately 20 nM GPR30 is an integral membrane receptor residing in the endoplasmic reticulum mediating intracellular signaling responses triggered by ligands such as estradiol G-15 specifically inhibits GPR30-mediated pathways without significantly interacting with estrogen receptors ER or ER even at higher concentrations In cellular studies G-15 blocks estrogen- or G-1-induced elevations of intracellular calcium and PI3K activation In vivo research demonstrates that G-15 disrupts estradiol-associated improvements in spatial learning tasks emphasizing its utility in investigating GPR30 function and estrogen signaling mechanisms

Catalog No. 50-223-9971