G418 disulfate, 50mg/ml solution, Thermo Scientific Chemicals

Description

G418 sulfate, geneticin, CAS # 108321-42-2, is an antibiotic closely related to Gentamicin B, the common aminoglycoside antibiotic.

G418 disulfate is used for selection and maintenance of prokaryotic and eukaryotic cells transfected with a iNOS promoter construct and neomycin resistance gene. Optimal concentrations for selection and maintenance vary by cell lines.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea
• G418 is bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis

Applications

• G418 sulfate can be used for the selection of genetically engineered cells in both eukaryotes and prokaryotes
• Laboratory-grade for applications such as biochemistry

Specifications

Chemical Identifiers

• CAS: 108321-42-2
• Molecular Formula: C20H44N4O18S2
• Molecular Weight (g/mol): 692.70
• MDL Number: MFCD00058314
• InChI Key: UHEPSJJJMTWUCP-KETIWVBHNA-N
• Synonym: Geneticin
• PubChem CID: 134129582
• IUPAC Name: (2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2S,3S,4R,6S)-4,6-diamino-3-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-(1-hydroxyethyl)oxane-3,4-diol; bis(sulfuric acid)
• SMILES: OS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O

• Type: G418 Disulfate
• Physical Form: Liquid
• Concentration: 50mg/ml solution
• Quantity: 50 mL
• Solubility Information: Difficult to mix.
• Formula Weight: 692.71
• Chemical Name or Material: G418 disulfate

Safety and Handling

Hazard Category	H317-H334
Precautionary Statement	P261-P272-P280g-P285-P302+P352-P304+P341-P333+P313-P342+P311-P363-P501c
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only