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Invitrogen™ GAD65 Polyclonal Antibody
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Catalog No. PIPA522260
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100 μL
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PIPA522260 100 μL
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Catalog No. PIPA522260 Supplier Invitrogen™ Supplier No. PA522260
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: mouse brain, rat brain. Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (86%), Dog (96%), Pig (95%), Rhesus Monkey (100%), Bovine (93%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

GAD65 (glutamic acid decarboxylase-65) are present in autoimmune disorders such as insulin-dependent (type1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GAD65
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene GAD2
Gene Accession No. P48320, Q05329, Q05683
Gene Alias 6330404F12Rik; 65 kDa glutamic acid decarboxylase; GAD(65); GAD2; Gad-2; GAD65; GAD-65; Glutamate decarboxylase 2; Glutamate decarboxylase 2 (islet); glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 65 kDa isoform; Glutamate decarboxylase-2 (pancreas); glutamic acid decarboxylase 2; glutamic acid decarboxylase 65; MGC161605; MGC161607; RP11-420F12.2
Gene Symbols GAD2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the C-terminus region of human GAD65. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14417, 24380, 2572
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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