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Invitrogen™ GAD67 Monoclonal Antibody (OTI3G9)
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Catalog No. PIMA524909
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100 μL
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PIMA524909 100 μL
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Catalog No. PIMA524909 Supplier Invitrogen™ Supplier No. MA524909
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Description

Mouse Monoclonal Antibody

GAD67 Monoclonal Antibody for ICC/IF, IHC (P), IP, Western Blot

GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predominant GAD-67 form and the minor GAD-25 form.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GAD67
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone OTI3G9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene GAD1
Gene Accession No. P18088, P48318, Q99259
Gene Alias 67 kDa glutamic acid decarboxylase; 67kDa glutamate decarboxylase 1; CPSQ1; EGK_04525; EP10; FLJ45882; GAD; GAD 1; GAD 67; GAD1; Gad-1; GAD25; GAD44; Gad67; GAD-67; Glutamate decarboxylase 1; Glutamate decarboxylase 1 (brain); glutamate decarboxylase 1 (brain, 67kDa); glutamate decarboxylase 1 isoform GAD67; glutamate decarboxylase 1 variant GAD67NT; glutamate decarboxylase 67 kDa isoform; GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE); glutamic acid decarboxylase; glutamic acid decarboxylase 1; glutamic acid decarboxylase isoform 67; OTTHUMP00000041055; SCP
Gene Symbols GAD1
Host Species Mouse
Immunogen Full length human recombinant protein of GAD1 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14415, 24379, 2571
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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