Invitrogen™ GALR2 Recombinant Rabbit Monoclonal Antibody (7H43L56)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ 703729

Catalog No. 70-372-9

Description

This antibody is predicted to react with Mouse, Rat, Bovine.

GalR2 expression has been documented widely in the brain and in peripheral tissues including small intestine, heart, kidney, and liver. Localization data from rat CNS indicate high levels of expression in dorsal root ganglia, amygdala, and Purkinje neurons. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: GALR2
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: O43603
• Gene Symbols: Galr2
• Immunogen: Protein corresponding to human GALR2 [aa300-aa387].
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Clone: 7H43L56
• Conjugate: Unconjugated
• Gene: Galr2
• Gene Alias: Gal receptor 2; Gal-2 receptor; GAL2-R; Galanin r2 receptor; galanin receptor 2; galanin receptor type 2; Galanin-2 receptor; Galnr2; GALR2; Gal-r2; GALR-2; mGalR; MGC125983; MGC125984
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 8811
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid