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Enzo Life Sciences Gambogic amide (1mg). CAS: 286935-60-2
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Supplier:  Enzo Life Sciences BMLN1590001

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A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM (see reference S.-W. Jang, et al. 2007). Purity: ≥95% (HPLC). Solubility: Soluble in DMSO (20mg/ml) or ethanol (20mg/ml). Long Term Storage: -20°C.

Catalog No. 50-201-1174


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