Invitrogen™ Gata-3 Monoclonal Antibody (TWAJ), Brilliant Violet™ 605, eBioscience™, Invitrogen™

Catalog No.	Quantity
40-699-6642	100 Tests
40-699-6641	25 Tests

Catalog No. 40-699-6642 Supplier Invitrogen™ Supplier No. 406996642

Description

Rat Monoclonal Antibody

Gata-3 Monoclonal antibody specifically detects Gata-3 in Human, Mouse, Porcine, Rhesus Monkey samples. It is validated for Flow Cytometry

The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells or macrophages. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.

Specifications

• Antigen: Gata-3
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: TWAJ
• Concentration: 5 μL/Test
• Conjugate: Brilliant Violet 605
• Formulation: PBS with BSA and 0.09% sodium azide; pH 7.2
• Gene: GATA3
• Gene Accession No.: P23771, P23772
• Gene Alias: EGK_19445; GATA binding factor-3; GATA binding protein 3; GATA binding protein-3; GATA3; Gata-3; GATA-binding factor 3; GATA-binding protein 3; HDR; HDRS; jal; MGC2346; MGC5199; MGC5445; Trans-acting T-cell-specific transcription factor GATA-3; Transacting T-cell-specific transcription factor GATA-3
• Gene Symbols: GATA3
• Host Species: Rat
• Purification Method: Affinity chromatography
• Quantity: 100 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 14462, 2625, 713840, 733631
• Target Species: Human, Mouse, Pig, Rhesus Macaque
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b κ