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Invitrogen™ GATSL3 Polyclonal Antibody

Catalog No. PIPA578683
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100 μL
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PIPA578683 100 μL
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Catalog No. PIPA578683 Supplier Invitrogen™ Supplier No. PA578683

Description

Rabbit Polyclonal Antibody

Positive Control: MCF-7, MDA-MB-231 Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

GATSL3 functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GATSL3
Applications Western Blot
Classification Polyclonal
Concentration 1.9 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Castor1
Gene Accession No. Q8WTX7
Gene Alias 2410008K03Rik; CASTOR1; cellular arginine sensor for mTORC1 protein 1; Cytosolic arginine sensor for mTORC1 subunit 1; Gats protein; GATS protein like 3; GATS protein-like 3; GATSL3; GATS-like protein 3; GATS-like protein 3; cytosolic arginine sensor for mTORC1 subunit 1; RGD1304774
Gene Symbols Castor1
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human GATSL3. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 652968
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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