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Invitrogen™ GBP1 Polyclonal Antibody
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Catalog No. PIPA595013
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100 μg
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PIPA595013 100 μg
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Catalog No. PIPA595013 Supplier Invitrogen™ Supplier No. PA595013
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: U87 whole cell, HELA whole cell, MCF-7 whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

GBP1 or guanlyate binding protein 1 is a 68 kDa GTPase and member of the GTPase1 family of molecules. GBP1 expression is induced by Interferon g as well as other inflammatory cytokines including IL-1a, IL-1b and TNF-a. Induction of GBP1 expression by poly I:C, a prototypical TLR3 ligand, as well as GBP1 expression dependency on NF-kB and IFNa response elements implicate TLR pathway involvement. Inversely proportional expression of GBP1 and MMP-1 as well as other related molecules to adhesion and migration show a clear functional role of GBP1 in suppressing angiogenesis and migration especially of endothelial cells. As a regulatory molecule it is centrally involved in signal transduction of inflammatory and cell migration networks.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GBP1
Applications Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
Gene GBP1
Gene Accession No. P32455
Gene Alias GBP1; Gbp-1; Gbp2b; GTP-binding protein 1; guanine nucleotide-binding protein 1; guanylate binding protein 1; guanylate binding protein 1, interferon-inducible; guanylate binding protein 1, interferon-inducible, 67kDa; guanylate binding protein 2b; guanylate nucleotide binding protein 1; guanylate-binding protein 1; huGBP-1; interferon-gamma-inducible protein MAG-1; interferon-induced guanylate-binding protein 1; Mag-1; Mpa1; Mpa-1
Gene Symbols GBP1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human GBP1 (566-589aa QKESRIMKNEIQDLQTKMRRRKAC).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2633
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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