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Tocris Bioscience™ GBR 12909 dihydrochloride

Selective DA uptake inhibitor; also σ ligand

Supplier:  Tocris Bioscience™ 0421/50

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Catalog No. 04-215-0

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GBR 12909 dihydrochloride is a potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has >100-fold lower affinity for the noradrenaline and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.


1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Soluble to 50mM in DMSO
Observed MW: 523.49
50 mg
Safety and Handling

Safety and Handling

Recommended Storage : Desiccate at Room Temperature



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