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Invitrogen™ Gemin 3 Monoclonal Antibody (12H12)
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Catalog No. 01674893
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Catalog No. Quantity
01-674-893 100 μL
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Catalog No. 01-674-893 Supplier Invitrogen™ Supplier No. MA15779
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Description

Mouse Monoclonal Antibody

MA1-5779 detects Gemin3 in human samples. MA1-5779 has been successfully used in Western blot, immunoprecipitation, immunofluorescence and ELISA procedures. MA1-5779 detects a band of approximately 105 kDa. The MA1-5779 immunogen is recombinant 6His-tag COOH-terminal domain of Gemin3.

Gemin 3 is a member of the DEAD box protein family which are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. DEAD box proteins such as Gemin 3 are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of DEAD box family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Gemin 3 has an ATPase activity and a component of the survival of motor neurons (SMN) complex. The Gemin 3 protein may play a catalytic role in the function of the SMN complex on RNPs. Diseases associated with Gemin 3 protein dysfunction include spinal muscular dystrophy and muscular atrophy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Gemin 3
Applications ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 12H12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene Ddx20
Gene Accession No. Q9JJY4, Q9UHI6
Gene Alias component of gems 3; DDX 20; DDX20; DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein 20; DEAD box protein DP 103; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD/H BOX 20; DEAD-box helicase 20; DEAD-box protein DP103; DKFZP434H052; DP 103; Dp103; GEMIN3; Gemin-3; I79_021005; probable ATP-dependent RNA helicase DDX20; putative ATP-dependent RNA helicase DDX20; regulator of steroidogenic factor 1; ROSF-1; SMN-interacting protein
Gene Symbols Ddx20
Host Species Mouse
Immunogen Recombinant 6His-tag COOH-terminal domain of Gemin3 (amino acids 368-548) from SP2/0 cellsal domain of Gemin3.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100752364, 11218, 53975, 84473
Target Species Human, Mouse, Rat, Hamster
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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