GEMIN2 Monoclonal Antibody (OTI4B3), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA808759

Catalog No. 50-168-2353

Description

SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.

Specifications

• Antigen: GEMIN2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O14893
• Gene Symbols: GEMIN2
• Immunogen: Full length human recombit protein of human GEMIN2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI4B3
• Conjugate: Unconjugated
• Gene: GEMIN2
• Gene Alias: SIP1, SIP1-delta
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8487
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid