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Invitrogen™ Gemtuzumab Chimeric Recombinant Rabbit Monoclonal Antibody (hP67.6 (Gemtuzumab))
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Catalog No. PIMA547867
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200 μg
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PIMA547867 200 μg
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Catalog No. PIMA547867 Supplier Invitrogen™ Supplier No. MA547867
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: Recognises human CD33.

Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheamicin per mole of antibodyLabel. The antibody is specifically directed against the CD33 antigen present on leukemic myeloblasts in most patients with acute myeloid leukemia (AML). By binding to the CD33 antigen on tumors, the cytotoxic agent blocks the growth of cancerous cells and causes cell death.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Gemtuzumab Chimeric
Applications Flow Cytometry, Immunocytochemistry
Classification Recombinant Monoclonal
Clone hP67.6 (Gemtuzumab)
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Alias CDP-771; CMA-676 (ADC); gemtuzumab ozogamicin; hP67.6; hP67.6-calicheamicin (ADC); WAY-CMA-676
Host Species Rabbit
Immunogen Gemtuzumab was generated by huminization of the murine P67.6 clone, raised against CD33-transfected FMY9S5 cells of human origin.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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