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Thermo Scientific™ GeneBLAzer™ 5TH1A-Gα15-NFAT-bla CHO-K1 Cells

Catalog No. K1712
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Description

GeneBLAzer™ 5HT1A Gα15-NFAT-bla CHO-K1 cells contain the human 5-HT Receptor 1A (5HT1A) stably integrated into the GeneBLAzer™ Gα15-NFAT-bla CHO-K1 cell line.

GeneBLAzer™ 5HT1A Gα15-NFAT-bla CHO-K1 cells contain the human 5-HT Receptor 1A (5HT1A) stably integrated into the GeneBLAzer™ Gα15-NFAT-bla CHO-K1 cell line. GeneBLAzer™ Gα15-NFAT-bla CHO-K1 cells (Cat. no. K1537) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element and the Promiscuous G protein, Gα15.

The GeneBLAzer™ 5HT1A Gα15-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of 5-CT. In addition, GeneBLAzer™ 5HT1A Gα15-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

Agonists and antagonists of the 5HT receptors are in various stages of clinical trials for the treatment of neurological disorders like anxiety, insomnia, and depression.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.

TRUSTED_SUSTAINABILITY

Specifications

Accession Number NM_000524
Assay Entry Cell-based beta lactamase reporter gene
Cell State Dividing Cells
Content And Storage LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol.

Includes:
• GeneBLAzer™ 5HT1A Gα15-NFAT-bla CHO-K1 cells
• GeneBLAzer™ 5HT1A Gα15-NFAT-bla CHO-K1 Assay Protocol
• Certificate of Analysis

The GeneBLAzer™ 5HT1A Gα15 CHO-K1 DA cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
Detection Method Fluorescence
For Use With (Application) FRET
Gene Symbol 5HT1A
Population Status Single Cell Clone Origin
Product Line GeneBLAzer
Quantity 2 x 106 Cells
Reporter Gene BLA (Beta-Lactamase)
Target Entry 5HT1A, HTR1A
Cell Line CHO-K1
System Type GeneBLAzer™
Druggable Target GPCR
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For Research Use Only. Not for use in diagnostic procedures.

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