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Thermo Scientific™ GeneBLAzer™ MC3R-CRE-bla CHO-K1 Cells

Catalog No. K1744
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Catalog No. K1744 Supplier Thermo Scientific™ Supplier No. K1744
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Description

GeneBLAzer™ MC3R CRE-bla CHO-K1 cells contain the human Melanocortin Receptor 3 (MC3R) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line.

GeneBLAzer™ MC3R CRE-bla CHO-K1 cells contain the human Melanocortin Receptor 3 (MC3R) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line. CellSensor™ CRE-bla CHO-K1 cells (Cat. No. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.

The GeneBLAzer™ MC3R CRE-bla CHO-K1 DA cells are functionally validated for Z' and EC50 concentrations of NDP-α-MSH. In addition, GeneBLAzer™ MC3R CRE-bla CHO-K1 DA cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

The melanocortin-3 receptor (MC3R) is primarily expressed in the hypothalamus, and plays an important role in the regulation of energy homeostasis. MC3R recognizes all of the melanocortin peptides, and notably binds - -MSH with greater affinity than the other melanocortin receptors. MC3R-deficient (MC3R-/-) mice demonstrate increased fat mass, higher feeding efficiency, and reduced lean body mass. To date only one mutation of MC3R has been identified to be associated with human obesity. Functional analysis of this mutation indicated a complete loss of agonist-mediated receptor activation.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.

TRUSTED_SUSTAINABILITY

Specifications

Accession Number NM_019888.2
Assay Entry Cell-based beta lactamase reporter gene
Cell State Dividing Cells
Content And Storage LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol.

Includes:
• GeneBLAzer™ MC3R CRE-bla CHO-K1 cells
• GeneBLAzer™ MC3R CRE-bla CHO-K1 Assay Protocol
• Certificate of Analysis

The GeneBLAzer™ MC3R CRE-bla CHO-K1cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
Detection Method Fluorescence
For Use With (Application) FRET
Gene Symbol MC3R
Population Status Single Cell Clone Origin
Product Line GeneBLAzer
Quantity 2 x 106 Cells
Reporter Gene BLA (Beta-Lactamase)
Target Entry MC3R
Cell Line CHO-K1
System Type GeneBLAzer™
Druggable Target GPCR
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For Research Use Only. Not for use in diagnostic procedures.

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