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  5. Tocris Bioscience™ Genistein

Tocris Bioscience™ Genistein
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Catalog No. 111050
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

EGFR kinase inhibitor. Also estrogen and PPARγ ligand

Genistein is a phytoestrogen with a wide range of biological actions. Genistein inhibits protein tyrosine kinases including epidermal growth factor receptor kinase, binds to PPARγ and estrogen receptors and acts as an agonist at GPER. Genistein inhibits aggregation and fibrilization of Aβ42 and amylin37 (hiAPP). In Huntington's disease fibroblast cells, Genistein reduces intracellular mutant huntingtin (mHTT) aggregates and induces degradation of mHTT; in a cellular model of Huntington's disease, Genistein corrects the mutant phenotype through stimulation of autophagy.

Chemical Identifiers

CAS 446-72-0
Molecular Formula C15H10O5

Specifications

Quantity 50 mg
Formula Weight 270.24
Purity >98%
Molecular Weight (g/mol) 270.24
Chemical Name or Material Genistein

Safety and Handling

Recommended Storage Desiccate at -20°C
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