GFI1 Mouse anti-Human, Clone: OTI6C10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF807139

Catalog No. 50-166-8132

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Gfi-1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.

Specifications

• Antigen: GFI1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: GFI1
• Gene Alias: GFI-1, GFI1A, SCN2, ZNF163
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2672
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI6C10
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q99684
• Gene Symbols: GFI1
• Immunogen: Full length human recombit protein of human GFI1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1