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GFI1 Mouse anti-Human, Clone: OTI6C10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF807139

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
Gfi-1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.Specifications
GFI1 | |
Monoclonal | |
Unconjugated | |
GFI1 | |
GFI-1, GFI1A, SCN2, ZNF163 | |
Mouse | |
Affinity Chromatography | |
RUO | |
2672 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Western Blot | |
OTI6C10 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
Q99684 | |
GFI1 | |
Full length human recombit protein of human GFI1 produced in E.coli. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
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