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Apexbio Technology LLC GI 254023X 260264-93-5 5mg
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Supplier:  Apexbio Technology LLC A44365

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GI 254023X (CAS 260264-93-5) is a selective small-molecule inhibitor targeting ADAM10 (a disintegrin and metalloprotease 10) a membrane-associated protease involved in constitutive ectodomain shedding of diverse cell-surface proteins This compound exhibits potent inhibition against ADAM10 with an IC50 of approximately 5 3 nM and displays a selectivity profile over ADAM17 (TACE) by more than 100-fold Research studies have demonstrated that GI 254023X effectively reduces constitutive cleavage of fractalkine (CX3CL1) in ECV-304 transfectants in vitro Moreover in a mouse model of vascular injury induced by Staphylococcus aureus -hemolysin GI 254023X treatment was associated with delayed progression of endothelial damage Currently GI 254023X remains at the preclinical research stage

Catalog No. 50-000-61632


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