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  5. Tocris Bioscience™ Gilteritinib

Tocris Bioscience™ Gilteritinib
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Catalog No. 789150
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78-915-0 50 mg
78-911-0 10 mg
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Catalog No. 78-915-0 Supplier Tocris Bioscience™ Supplier No. 7891/50
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Description

Potent FLT3 inhibitor; also potently inhibits AXL

Gilteritinib is a potent Fms-like tyrosine kinase 3 (FLT3) and AXL inhibitor (IC50 = 0.29 nM and 0.73 nM, for FLT3 and AXL, respectively). In vivo, Gilteritinib reduces tumor growth and improves survival in xenograft and intra-bone marrow transplantation models of FLT3 mutated acute myeloid leukemia. Gilteritinib is orally bioavailable.

Specifications

Chemical Name or Material 6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide
CAS 1254053-43-4
Quantity 50 mg
Target Flt-3/Flk-2/CD135
Molecular Formula C29H44N8O3
Purity 0.98
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