Glucocorticoid receptor Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-4220	150 μL

Catalog No. 50-173-4220 Supplier Proteintech Group Inc Supplier No. 240501AP150UL

Description

Rabbit Polyclonal Antibody

This antibody is specific to NR3C1. NR3C1 exists 16 isoforms and range of molecular weight is 54-94 kDa.

Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance.

Specifications

• Antigen: Glucocorticoid receptor
• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.43 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: NR3C1
• Gene Accession No.: P04150, P06536, P06537
• Gene Alias: GCCR, GCR, Glucocorticoid receptor, GR, GRL, NR3C1
• Gene Symbols: NR3C1
• Host Species: Rabbit
• Immunogen: Glucocorticoid receptor Fusion Protein Ag21146
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 14815, 24413, 2908
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG