Invitrogen™ GLUT1 Recombinant Rabbit Monoclonal Antibody (SA0377)

Catalog No.	Quantity
PIMA531960	100 μL

Catalog No. PIMA531960 Supplier Invitrogen™ Supplier No. MA531960

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Glucose transporter 1 (GLUT1), encoded by the SLC2A1 gene, is a facilitative glucose transporter that plays a pivotal role in the uptake of glucose across cell membranes, particularly in tissues with high-energy demands such as the brain, erythrocytes, and endothelial cells of the blood-brain barrier. GLUT1 is ubiquitously expressed and functions through a passive diffusion mechanism, allowing glucose to move down its concentration gradient. Its involvement in maintaining glucose homeostasis is crucial for cellular metabolism and energy production. Mutations in SLC2A1 can lead to GLUT1 deficiency syndrome, characterized by seizures, developmental delay, and movement disorders due to impaired glucose transport into the brain. GLUT1 also plays a significant role in cancer biology, where its overexpression is commonly observed in various tumors, facilitating the enhanced glucose uptake required for rapid tumor cell proliferation. This characteristic makes GLUT1 a potential target for cancer diagnostics and therapeutics. Additionally, GLUT1's regulation is influenced by factors such as hypoxia, insulin, and cellular stress, highlighting its adaptive role in different physiological and pathological states.

Specifications

• Antigen: GLUT1
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
• Classification: Recombinant Monoclonal
• Clone: SA0377
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 40% Glycerol, 0.05% BSA and 0.05% sodium azide; pH 7.4
• Gene: SLC2A1
• Gene Accession No.: P11166, P11167, P17809
• Gene Alias: choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity); CSE; DYT17; DYT18; DYT9; EIG12; glucose transporter glut1; glucose transporter type 1, erythrocyte/brain; glucose transporter type I; GLUT; Glut1; Glut-1; GLUT1DS; GLUTB; GT1; GTG1; Gtg3; HepG2 glucose transporter; HTLVR; human T-cell leukemia virus (I and II) receptor; MGC141895; MGC141896; PED; RATGTG1; receptor for HTLV-1 and HTLV-2; SDCHCN; Slc2a1; solute carrier family 2 (facilitated glucose transporter), member 1; Solute carrier family 2 a 1 (facilitated glucose transporter) brain; solute carrier family 2 member 1; solute carrier family 2, facilitated glucose transporter member 1; solute carrier family 2, member 1
• Gene Symbols: SLC2A1
• Host Species: Rabbit
• Immunogen: Synthetic peptide within Human GLUT1 aa 443-492.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 20525, 24778, 6513
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov