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AdipoGen GLUT2 rat pAb IN119
SDP

Supplier:  AdipoGen AG25B0043C050

Encompass_Preferred

Polyclonal Antibody. Recognizes rat GLUT2. Applications IHC, IP, WB. Source Rabbit. GLUT2 belongs to the family of glucose transporters GLUTs, encoded by the SLC2A genes, which comprises 14 isoforms. GLUT2 has a uniquely low affinity for glucose Km ~ 17mmol/l, and can also use mannose, galactose and fructose as low-affinity substrates. However, it has a high affinity for glucosamine Km ~ 0.8mmol/l. GLUT2 is expressed in liver, intestine, kidney and pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms. GLUT2 is also the major glucose transporter in the plasma membrane of hepatocytes. In pancreatic beta cells, GLUT2 is required for glucose-stimulated insulin secretion.

Catalog No. 50-256-3179


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