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Apexbio Technology LLC LY2606368 1234015-52-1 25mg
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Supplier:  Apexbio Technology LLC B108825

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LY2606368 (CAS 1234015-52-1) is a selective ATP-competitive inhibitor of checkpoint kinase 1 (CHK1) a serine/threonine kinase integral to the DNA damage response pathway In SW1990 pancreatic cancer cells LY2606368 exhibits potent inhibition of cell proliferation with an IC50 value of 1 5 nM The compound suppresses CHK1 autophosphorylation and induces phosphorylation of H2AX reflective of DNA damage signaling In vivo studies show that LY2606368 reduces tumor growth in SW1990 xenograft and SKOV3 orthotopic models and lowers tumor metastasis rates Due to low oral bioavailability administration is intravenous LY2606368 is under clinical investigation as an anticancer agent

Catalog No. 50-000-89601


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