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Invitrogen™ Glypican 2 Polyclonal Antibody
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Catalog No. PIPA5115299 Shop All Thermo Scientific Products
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PIPA5115299 100 μL
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Catalog No. PIPA5115299 Supplier Invitrogen™ Supplier No. PA5115299
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Glypican 2.

Glypican 2 (GPC2) is a gene located on chromosome 7q22.1, encoding a member of the glypican family of heparan sulfate proteoglycans that are attached to the cell surface via a glycosylphosphatidylinositol (GPI) anchor. Glypicans are involved in the regulation of cell growth, differentiation, and morphogenesis, primarily through their interactions with growth factors and morphogens in the extracellular environment. GPC2 is prominently expressed in the nervous system and plays a significant role in neural development, influencing processes such as neuronal growth and axon guidance. Alterations in GPC2 expression have been linked to neurodevelopmental disorders and certain cancers, such as neuroblastoma, where it can act as an oncofetal antigen. GPC2 is being investigated for its potential as a therapeutic target and biomarker in oncology due to its involvement in tumorigenesis and cancer progression. Research continues to explore its functional mechanisms and its implications in both neurobiology and cancer therapy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Glypican 2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene GPC2
Gene Accession No. P51653, Q8BKV1, Q8N158
Gene Alias 2410016G05Rik; cerebroglycan; cerebroglycan proteoglycan; glypican 2; glypican 2 (cerebroglycan); glypican proteoglycan 2, cerebroglycan proteoglycan; glypican-2; GPC2; HSPG M13; Secreted glypican-2
Gene Symbols GPC2
Host Species Rabbit
Immunogen A synthesized peptide derived from human GPC2(Accession Q8N158), corresponding to amino acid residues Y134-F184.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 171517, 221914, 71951
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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