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Invitrogen™ Glypican 3 Polyclonal Antibody
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Catalog No. PIPA5102528
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100 μL
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PIPA5102528 100 μL
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Catalog No. PIPA5102528 Supplier Invitrogen™ Supplier No. PA5102528
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GPC3.

GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Glypican 3
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GPC3
Gene Accession No. P13265, P51654, Q8CFZ4
Gene Alias defective in Simpson-Golabi-Behmel overgrowth syndrome; DGSX; glypican 3; glypican proteoglycan 3; glypican-3; Glypican-3 alpha subunit; Glypican-3 beta subunit; Gpc3; GTR22; GTR2-2; heparan sulphate proteoglycan; intestinal protein OCI-5; MXR7; OCI5; OCI-5; proteoglycan GPC3; SDYS; secreted glypican-3; SGB; SGBS; SGBS1
Gene Symbols GPC3
Host Species Rabbit
Immunogen A synthesized peptide derived from human GPC3(Accession P51654), corresponding to amino acid residues R39-M89.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14734, 25236, 2719
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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