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PeproTech GM-CSF Polyclonal Antibody, Biotin, PeproTech®, Invitrogen™

Catalog No. 500P65BT25
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500 μg
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Catalog No. Quantity
500P65BT25 25 μg
500P65BT50 50 μg
50-271-8462 500 μg
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Catalog No. 500P65BT25 Supplier PeproTech Supplier No. 500P65BT25UG
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Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Murine GM-CSF. Anti-Murine GM-CSF-specific antibody was purified by affinity chromatography and then biotinylated. Sandwich ELISA: To detect mGM-CSF by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25-1.0 μg/mL of this antibody is required. This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Murine GM-CSF (500-P65) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant mGM-CSF. Western Blot: To detect mGM-CSF by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant mGM-CSF is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. 500-P65BT-1MG will be provided as 2 x 500 μg

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GM-CSF
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugate Biotin
Formulation PBS with no preservative
Gene CSF2
Gene Accession No. P01587
Gene Alias colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim
Gene Symbols CSF2
Host Species Rabbit
Immunogen E.coli-derived Recombinant Murine GM-CSF.
Purification Method Antigen affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12981
Target Species Mouse
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
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