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GM-CSF Monoclonal Antibody (MP1-22E9), PE, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

$213.00 - $296.65

Specifications

Antigen GM-CSF
Clone MP1-22E9
Concentration 0.2 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-111-96
Encompass_Preferred
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Invitrogen™
12733181
50 μg
Each for $213.00
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50-112-2388
Encompass_Preferred
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Invitrogen™
12733182
100 μg
Each for $296.65

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Reg : $305.00

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Description

Description

Description: The MP1-22E9 antibody reacts with mouse granulocyte/macrophage - colony stimulating factor (GM-CSF). The MP1-22E9 antibody is a neutralizing antibody. Mouse GM-CSF is a 14 kDa factor produced mainly by activated T cells and macrophages. Other cell types, such as endothelium and fibroblasts, also secrete GM-CSF in response to TNF-alpha, IL-2, IL-1, and IFN-gamma. GM-CSF stimulates growth of macrophages, granulocytes and dendritic cells. GM-CSF is found as a membrane-bound form and also as a complex associated with the extracellular matrix. Non-glycosylated GM-CSF is biologically active. Applications Reported: MP1-22E9 has been reported for use in intracellular flow cytometric analysis. Applications Tested: This MP1-22E9 antibody is tested by intracellular staining and flow cytometric analysis of cultured mouse splencoytes. It is offered in 2 formats: - μg size: has been tested bu intracellular staining and flow cytometric analysis of cultured mouse splencoytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
Specifications

Specifications

GM-CSF
0.2 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim
CSF2
Primary
4°C, store in dark, DO NOT FREEZE!
CSF2
MP1-22E9
Flow Cytometry
PE
Rat
Mouse
P01587
12981
IgG2a κ
Affinity chromatography
Antibody
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