GNAS Mouse anti-Human, Clone:7G6G5, Abnova™

Catalog No.	Quantity
89-333-185	100 μg

Catalog No. 89-333-185 Supplier Abnova Corporation Supplier No. MAB16693

Description

Mouse monoclonal antibody raised against recombinant human GNAS.

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5′ exons. Some transcripts contains a differentially methylated region (DMR) at their 5′ exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq]

Specifications

• Antigen: GNAS
• Applications: ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
• Classification: Monoclonal
• Clone: 7G6G5
• Conjugate: Unconjugated
• Description: GNAS complex locus
• Dilution: ELISA (1:10000)
  Western Blot (1:500-1:2000)
  Immunohistochemistry
  Immunocytochemistry (1:200-1:1000)
  Flow Cytometry (1:200-1:400)
  The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% sodium azide)
• Gene: GNAS
• Gene Alias: AHO, C20orf45, GNAS1, GPSA, GSA, GSP, MGC33735, NESP, PHP1A, PHP1B, POH, dJ309F20.1.1, dJ806M20.3.3
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acid 42-188 of human GNAS from E. coli.
• Quantity: 100 μg
• Gene ID (Entrez): 2778
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1