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Tocris Bioscience™ GNE 2861

Catalog No. 64905
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Quantity:
5 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Inhibitor of group II p21 activated kinases

GNE 2861 is an inhibitor of group II p21 activated kinases (PAK; IC50 values are 7.5, 126 and 36 nM for PAK4, PAK5 and PAK6, respectively). Displays selectivity for group II PAK over a panel of 222 kinases. Inhibits tumor cell proliferation, migration and invasion in two breast cancer cell lines. Also sensitizes tamoxifen-resistant breast cancer cell lines to tamoxifen (Cat. No. 6342) via PAK4-dependent regulation of estrogen receptor α (ERα) target gene expression.

Specifications

Chemical Name or Material 1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol
CAS 1394121-05-1
Quantity 5 mg
Molecular Formula C22H26N6O2
Formula Weight 406.48
Purity 98%
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