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Tocris Bioscience™ GNE 2861
SDP

Catalog No. 64905
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64-905 5 mg
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Catalog No. 64-905 Supplier Tocris Bioscience™ Supplier No. 6490/5

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Description

Inhibitor of group II p21 activated kinases

GNE 2861 is an inhibitor of group II p21 activated kinases (PAK; IC50 values are 7.5, 126 and 36 nM for PAK4, PAK5 and PAK6, respectively). Displays selectivity for group II PAK over a panel of 222 kinases. Inhibits tumor cell proliferation, migration and invasion in two breast cancer cell lines. Also sensitizes tamoxifen-resistant breast cancer cell lines to tamoxifen (Cat. No. 6342) via PAK4-dependent regulation of estrogen receptor α (ERα) target gene expression.

Specifications

Chemical Name or Material 1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol
CAS 1394121-05-1
Quantity 5 mg
Molecular Formula C22H26N6O2
Formula Weight 406.48
Purity 98%
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