Invitrogen™ GNE Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555559

Catalog No. PIPA555559

Description

Immunogen sequence: VPFDQFIQLV AHAGCMIGNS SCGVREVGAF GTPVINLGTR QIGRETGENV LHVRDADTQD KILQALHLQF GKQYPCSKIY GDGNAVPRIL KFLKSIDLQE PLQKKFCFPP VKENISQDID HILETLSALA VDLGGTNLRV A Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.

Specifications

• Antigen: GNE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GNE
• Gene Alias: 2310066H07Rik; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase; GNE; IBM2; ManAc kinase; N-acetylmannosamine kinase; N-acylmannosamine kinase; NM; Uae1; UDP-GlcNAc-2-epimerase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase (hydrolyzing); UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; Uridine diphosphate-N-acetylglucosamine-2-epimerase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10020
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y223
• Gene Symbols: GNE
• Immunogen: Recombinant protein corresponding to Human GNE. Recombinant protein control fragment (Product #RP-89765).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov