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Sigma Aldrich Fine Chemicals Biosciences Gold nanoparticles 15 nm d

Supplier:  Sigma Aldrich Fine Chemicals Biosciences 7653251ML

Encompass

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which have Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.x2020x2020x2020x2020

Catalog No. 50-290-7029


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