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Invitrogen™ GPR120 Polyclonal Antibody
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Catalog No. PIPA5120658
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PIPA5120658 100 μL
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Catalog No. PIPA5120658 Supplier Invitrogen™ Supplier No. PA5120658
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Description

Rabbit Polyclonal Antibody

Positive test controls include: HT-29, BxPC-3, RAW264.7, Mouse large intestine, Rat large intestine, Rat small intestine. Immunogen sequence: NPILYNMTLC RNEWKKIFCC FWFPEKGAIL TDTSVKRNDL SIISG.

An EST for GPR120 has been isolated from a human colon cancer library. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GPR120
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene FFAR4
Gene Accession No. Q2AC31, Q5NUL3, Q7TMA4
Gene Alias AI552415; BMIQ10; FFAR4; Free fatty acid receptor 4; G protein-coupled receptor 120; GPCR120; Gpr120; Gpr129; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; G-protein-coupled receptor GT01; GT01; KPG_013; O3FAR1; omega-3 fatty acid receptor 1; PGR4
Gene Symbols FFAR4
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 333-377 of human FFAR4 (NP_859529.2).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 107221, 294075, 338557
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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