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Invitrogen™ GPR18 Polyclonal Antibody
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Catalog No. PIPA3006
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PIPA3006 100 μL
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Catalog No. PIPA3006 Supplier Invitrogen™ Supplier No. PA3006
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Description

Rabbit Polyclonal Antibody

IHC (P) analysis shows positive staining of GPR18 in human enteric ganglion tissue. WB analysis shows GPR18 in glycoprotein-enriched fractions from GPR18 overexpressing 293 cells. A band of similar MW was also detected in GPR3 overexpressing 293 cells, suggesting some cross-reactivity with GPR3 or enhanced detection of basal GPR18 in the enriched fractions. While GPR18 has a theoretical MW of ~ 38kD, the observed band in a WB runs at ~70kD due to enrichment of the glycosylated receptor.

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR18 is an orphan G protein-coupled receptor found at high levels in the testis, small intestines and cells associated with the immune system including lymphocytes, thymus and spleen. GPR18 has been found to be a receptor for endogenous lipid neurotransmitters, several of which also bind to cannabinoid receptors. Some ligands described to be GPR18 agonists or partial agonists include N-Arachidonoylglycine, Abnormal cannabidiol, O-1602, AM-251, Cannabidiol, delta 9-Tetrahydrocannabinol, N-arachidonoyl ethanolamine and Arachidonylcyclopropylamide. Antagonists include the synthetic cannabidiol related compounds CID-85469571 and O-1918.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GPR18
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation whole serum with 0.05% sodium azide
Gene GPR18
Gene Accession No. Q14330
Gene Alias EMBL:AAI28783.1}; G protein-coupled receptor 18; GPCRW; Gpr18; gpr18 {ECO:0000312; G-protein coupled receptor 18; NAGly receptor; N-arachidonyl glycine receptor; RP11-461N23.8
Gene Symbols GPR18
Host Species Rabbit
Immunogen KLH conjugated Cys-RKSFRSGSLRSLSNINSEML.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2841
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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