Invitrogen™ GPR18 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA3006

Catalog No. PIPA3006

Description

IHC (P) analysis shows positive staining of GPR18 in human enteric ganglion tissue. WB analysis shows GPR18 in glycoprotein-enriched fractions from GPR18 overexpressing 293 cells. A band of similar MW was also detected in GPR3 overexpressing 293 cells, suggesting some cross-reactivity with GPR3 or enhanced detection of basal GPR18 in the enriched fractions. While GPR18 has a theoretical MW of ~ 38kD, the observed band in a WB runs at ~70kD due to enrichment of the glycosylated receptor.

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR18 is an orphan G protein-coupled receptor found at high levels in the testis, small intestines and cells associated with the immune system including lymphocytes, thymus and spleen. GPR18 has been found to be a receptor for endogenous lipid neurotransmitters, several of which also bind to cannabinoid receptors. Some ligands described to be GPR18 agonists or partial agonists include N-Arachidonoylglycine, Abnormal cannabidiol, O-1602, AM-251, Cannabidiol, delta 9-Tetrahydrocannabinol, N-arachidonoyl ethanolamine and Arachidonylcyclopropylamide. Antagonists include the synthetic cannabidiol related compounds CID-85469571 and O-1918.

Specifications

• Antigen: GPR18
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GPR18
• Gene Alias: EMBL:AAI28783.1}; G protein-coupled receptor 18; GPCRW; Gpr18; gpr18 {ECO:0000312; G-protein coupled receptor 18; NAGly receptor; N-arachidonyl glycine receptor; RP11-461N23.8
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: Conc. Not Determined
• Formulation: whole serum with 0.05% sodium azide
• Gene Accession No.: Q14330
• Gene Symbols: GPR18
• Immunogen: KLH conjugated Cys-RKSFRSGSLRSLSNINSEML.
• Regulatory Status: RUO
• Gene ID (Entrez): 2841
• Content And Storage: -20°C
• Form: Liquid

Safety and Handling

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