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Invitrogen™ GPR68 Polyclonal Antibody
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Catalog No. PA549323
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400 μL
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PA549323 400 μL
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Catalog No. PA549323 Supplier Invitrogen™ Supplier No. PA549323
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Description

Rabbit Polyclonal Antibody

Predicted to react with bovine and human based on sequence homology.

GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GPR68
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene GPR68
Gene Accession No. Q8BFQ3
Gene Alias BB131428; Brgr1; Brgrb; G protein-coupled receptor 68; GPR12A; Gpr68; G-protein coupled receptor 68; Ogr1; OGR-1; ovarian cancer G protein-coupled receptor, 1; ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor
Gene Symbols GPR68
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 200-225 amino acids from the Central region of mouse Gpr68.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 238377
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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