Invitrogen™ GPX1 Monoclonal Antibody (A6-C0-B9)

Catalog No.	Quantity
PIMA534920	100 μL

Catalog No. PIMA534920

Supplier: Invitrogen™ MA534920

Description

Mouse Monoclonal Antibody

Positive Control: THP-1, human liver tissue, human kidney tissue, HepG2.

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.

Specifications

• Antigen: GPX1
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: A6-C0-B9
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene: GPX1
• Gene Accession No.: P07203
• Gene Alias: AI195024; AL033363; Cellular glutathione peroxidase; CGPx; cytosolic glutathione peroxidase; glutathione peroxidase; glutathione peroxidase 1; Gpx; Gpx1; GPx-1; GPXD; GSHPx; GSHPX1; GSHPx-1; HGNC:4553; MGC14399; MGC88245; OTTHUMP00000210766; Selenium-dependent glutathione peroxidase 1
• Gene Symbols: GPX1
• Host Species: Mouse
• Immunogen: Recombinant protein within Human Glutathione Peroxidase 1 aa 20-203.
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2876
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b