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  7. GR 159897, Tocris Bioscience™

GR 159897, Tocris Bioscience™

Catalog No. 127450
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12-745-0 50 mg
12-741-0 10 mg
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Catalog No. 12-745-0 Supplier R&D Systems Supplier No. 1274/50

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Description

Non-peptide, potent NK2 antagonist

A potent, selective, non-peptide, orally active neurokinin NK2 receptor antagonist. Competes for binding of [3H]GR100679 to hNK2-transfected CHO cells with a pKi of 9.5. Inhibits NK2 receptor-mediated contraction of guinea pig trachea with a pA2 of 8.7. Anxiolytic in vivo.

Chemical Identifiers

CAS 158848-32-9
Molecular Formula C23H27FN2O2S
Molecular Weight (g/mol) 414.539
InChI Key BANYJBHWTOJQDU-GDLZYMKVSA-N
Synonym 5-fluoro-3-2-4-methoxy-4-r-phenylsulphinyl methyl-1-piperidinyl ethyl-1h-indole, d02ywv, r-5-fluoro-3-2-4-methoxy-4-phenylsulfinyl methyl piperidin-1-yl ethyl-1h-indole, 5-fluoro-3-2-4-methoxy-4-r-phenylsulfinyl methyl piperidin-1-yl ethyl-1h-indole, 5-fluoro-3-2-4-methoxy-4-r phenylsulfinyl methyl-1-piperidinyl ethyl-1h-indole, r-1-2-5-fluoro-1h-indol-3-yl ethyl-4-methoxy-4-phenyl-sulfinyl methyl-piperidine, 3-2-4-r-benzenesulfinyl methyl-4-methoxypiperidin-1-yl ethyl-5-fluoro-1h-indole
PubChem CID 9953599
IUPAC Name 5-fluoro-3-[2-[4-methoxy-4-[[(R)-phenylsulfinyl]methyl]piperidin-1-yl]ethyl]-1H-indole
SMILES COC1(CCN(CC1)CCC2=CNC3=C2C=C(C=C3)F)CS(=O)C4=CC=CC=C4

Specifications

Quantity 50 mg
Formula Weight 414.54
Percent Purity >97%
Chemical Name or Material GR 159897

Safety and Handling

Recommended Storage Desiccate at -20°C
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