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Invitrogen™ GRAMD1A Monoclonal Antibody (1-E4)
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Catalog No. PIMA532884
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PIMA532884 100 μL
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Catalog No. PIMA532884 Supplier Invitrogen™ Supplier No. MA532884
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Description

Mouse Monoclonal Antibody

GRAMD1A Monoclonal Antibody for ICC/IF, IHC (P), Western Blot

Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain. At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER. May play a role in tumor progression. Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). [UniProt].
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Specifications

Antigen GRAMD1A
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
Classification Monoclonal
Clone 1-E4
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
Gene GRAMD1A
Gene Accession No. Q8VEF1, Q96CP6
Gene Alias 1300003M23Rik; AI415002; AW547240; D7Bwg0611e; GRAM domain containing 1A; GRAM domain-containing protein 1A; GRAMD1A; KIAA1533; Protein Aster-A
Gene Symbols GRAMD1A
Host Species Mouse
Immunogen Recombinant protein within Human GRAMD1A aa 1-724.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 52857, 57655
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgM
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