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Invitrogen™ Granzyme B Monoclonal Antibody (GB12), PE
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MHGB04

Description
According to the literature this antibody recognizes granzyme B1 . Each lot is tested by flow cytometry using peripheral blood leukocytes. Based on this testing it is recommended that 5 μL of antibody be used per 1 x 10^6 cells. For R-PE conjugates excitation 488 nm/peak emission 575 nm. Matching isotype control is available: Ms IgG1 R-PE #MG104.
Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis. Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.
Specifications
Granzyme B | |
Monoclonal | |
0.15 mg/mL | |
PBS with 4mg/mL BSA, 10% sucrose and 0.1% sodium azide | |
P10144 | |
GZMB | |
Human Granzyme B. | |
500 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Flow Cytometry | |
GB12 | |
PE | |
GZMB | |
AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E | |
Mouse | |
Purified | |
RUO | |
3002 | |
4°C | |
Liquid | |
Responsibly packaged |
Safety and Handling
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