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Granzyme B Mouse anti-Human, RB545, Clone: GB11, BD Horizon™

Catalog No. BDB569290 Shop All BD Biosciences Products
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BDB569290 100 Tests
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Catalog No. BDB569290 Supplier BD Biosciences Supplier No. 569290
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Description

Mouse Monoclonal Antibody

The GB11 antibody specifically reacts with human granzyme B, a serine protease of approximately 32 kDa. Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin. In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes. Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis. Granzyme B may also be involved in the hydrolysis of extracellular matrix components. Detectable levels of granzyme B have been detected in sera from healthy volunteers. The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from an NK cell line.

Granzyme B Monoclonal antibody specifically detects Granzyme B in Human samples. It is validated for Intracellular Staining (Flow Cytometry)
TRUSTED_SUSTAINABILITY

Specifications

Antigen Granzyme B
Applications Flow Cytometry
Classification Monoclonal
Clone GB11
Conjugate RB545
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias GZMB; Granzyme-2; CCPI; CGL1; CSPB; CTLA1; CTSGL1; GRB; HLP; SECT
Host Species Mouse
Immunogen Human Granzyme B
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3002
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to the dye under optimum conditions and unreacted dye was removed.
Form Purified
Isotype IgG1 κ
Excitation/Emission Excitation Source: Blue 488 nm, Excitation Max: 496 nm, Emission Max: 545 nm
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