Invitrogen™ GRB2 Monoclonal Antibody (11-B11)

Catalog No.	Quantity
PIMA534887	100 μL

Catalog No. PIMA534887

Supplier: Invitrogen™ MA534887

Description

Mouse Monoclonal Antibody

Positive Control: 293, MCF-7, HepG2, rat brain tissue, human colon cancer tissue,.

GRB 2 protein contains one SH2 domain flanked on both sides by an SH3 domain. In response to EGF, GRB 2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The GRB 2-Sos complex then binds the EGF receptor. These interactions play a critical role in the activation of the p21 ras signaling pathway.

Specifications

• Antigen: GRB2
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 11-B11
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
• Gene: GRB2
• Gene Accession No.: P62993
• Gene Alias: AA408164; abundant SRC homology; adapter protein GRB2; Adapter protein GRB2-A; ASH; ASH protein; EGFRBP-GRB2; epidermal growth factor receptor-binding protein GRB2; grb2; grb2.L; grb2-a; grb2-b; Grb3-3; growth factor receptor bound protein 2; growth factor receptor bound protein 2 L homeolog; growth factor receptor-bound protein 2; Growth factor receptor-bound protein 2-A; growth factor receptor-bound protein 3; HT027; hypothetical protein LOC535298; MST084; MSTP084; NCKAP2; OTTHUMP00000166097; OTTHUMP00000166098; protein Ash; SH2/SH3 adapter GRB2; SH2/SH3 adapter GRB2-A; SH2/SH3 adaptor Grb2; XELAEV_18044055mg
• Gene Symbols: GRB2
• Host Species: Mouse
• Immunogen: Recombinant protein within Human GRB2 aa 21-217.
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2885
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b