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Invitrogen™ GRIK1 Polyclonal Antibody
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Catalog No. PIPA520447
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100 μg
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Catalog No. Quantity
PIPA520447 100 μg
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Catalog No. PIPA520447 Supplier Invitrogen™ Supplier No. PA520447
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Description

Rabbit Polyclonal Antibody

A suggested positive control is P815 cell lysate. PA5-20447 can be used with blocking peptide PEP-0564. Antibodies should not be exposed to prolonged high temperatures.

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GRIK1
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Grik1
Gene Accession No. P39086, Q60934
Gene Alias A830007B11Rik; D16Ium24; D16Ium24e; EAA3; EEA3; excitatory amino acid receptor 3; GLR5; GluK1; GluK5; GLUR5; gluR-5; Glurbeta1; glutamate ionotropic receptor kainate type subunit 1; glutamate receptor; glutamate receptor 5; Glutamate receptor ionotropic, kainate 1; glutamate receptor subunit 5; glutamate receptor, ionotropic, kainate 1; GRIK1
Gene Symbols Grik1
Host Species Rabbit
Immunogen A 15 amino acid peptide near the carboxy terminus of the human Grik1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14805, 2897
Target Species Human, Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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