Invitrogen™ GRIK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520447

Catalog No. PIPA520447

Description

A suggested positive control is P815 cell lysate. PA5-20447 can be used with blocking peptide PEP-0564. Antibodies should not be exposed to prolonged high temperatures.

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.

Specifications

• Antigen: GRIK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Grik1
• Gene Alias: A830007B11Rik; D16Ium24; D16Ium24e; EAA3; EEA3; excitatory amino acid receptor 3; GLR5; GluK1; GluK5; GLUR5; gluR-5; Glurbeta1; glutamate ionotropic receptor kainate type subunit 1; glutamate receptor; glutamate receptor 5; Glutamate receptor ionotropic, kainate 1; glutamate receptor subunit 5; glutamate receptor, ionotropic, kainate 1; GRIK1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14805, 2897
• Content And Storage: 4°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P39086, Q60934
• Gene Symbols: Grik1
• Immunogen: A 15 amino acid peptide near the carboxy terminus of the human Grik1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG