GRM5 Rabbit anti-Human, Polyclonal, liquid, OriGene

Rabbit Polyclonal Antibody

Supplier:  OriGene TA890123

Catalog No. 50-168-4809

Description

The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse. Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR receptor may also be critically involved in limiting the deleterious effects on excitoxicity. In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA of the hippocampus.

Specifications

• Antigen: GRM5
• Classification: Polyclonal
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P41594
• Gene Symbols: GRM5
• Immunogen: Recombit protein of human GRM5
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: GRM5
• Gene Alias: GPRC1E, MGLUR5, PPP1R86, mGlu5
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2915
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid